Wednesday, April 30, 2014

Your Big Data Is Worthless if You Don't Bring It Into the Real World

In a generation, the relationship between the “tech genius” and society has been transformed: from shut-in to savior, from antisocial to society’s best hope. Many now seem convinced that the best way to make sense of our world is by sitting behind a screen analyzing the vast troves of information we call “big data.”
Just look at Google Flu Trends. When it was launched in 2008 many in Silicon Valley touted it as yet another sign that big data would soon make conventional analytics obsolete.
But they were wrong...

Reposted by:
Charles R. Davenport, Psy.D.
Licensed Psychologist
Charles R. Davenport, Psy.D., LLC.
Offices: Sarasota, FL and Venice, FL


Wednesday, April 23, 2014

Breakthroughs could lead to 'powerful treatment for depression'

With approximately 1 in 10 American adults reporting some form of depression, finding new ways to treat the disorder has been a major focus for researchers. Now, investigators from the University of Texas Southwestern Medical Center say they have made important breakthroughs in this field.

The researchers, including Dr. Jeffrey Zigman, associate professor of internal medicine and psychiatry at UT Southwestern, say they have uncovered an important mechanism by which ghrelin - a natural antidepressant hormone - works inside the brain. In addition, the team has uncovered a neuroprotective drug that they say has the potential to be a powerful treatment for depression...


Reposted by:
Charles R. Davenport, Psy.D.
Licensed Psychologist
Charles R. Davenport, Psy.D., LLC.
Offices: Sarasota, FL and Venice, FL


Psychotherapy for Insomnia Doubles Chance of Full Recovery From Depression

The *New York Times* includes an article: "Treating Insomnia to May Help Cure Depression" by Benedict Carey.

Here are some excerpts:

[begin excerpts]

Curing insomnia in people with depression could double their chance of a full recovery, scientists are reporting.

The findings, based on an insomnia treatment that uses talk therapy rather than drugs, are the first to emerge from a series of closely watched studies of sleep and depression to be released in the coming year.

The new report affirms the results of a smaller pilot study, giving scientists confidence that the effects of the insomnia treatment are real.

If the figures continue to hold up, the advance will be the most significant in the treatment of depression since the introduction of Prozac in 1987.

<snip>

"It would be an absolute boon to the field," said Dr. Nada L. Stotland, professor of psychiatry at Rush Medical College in Chicago, who was not connected with the latest research.

"It makes good common sense clinically," she continued.

"If you have a depression, you're often awake all night, it's extremely lonely, it's dark, you're aware every moment that the world around you is sleeping, every concern you have is magnified."

The study is the first of four on sleep and depression nearing completion, all financed by the National Institute of Mental Health.

They are evaluating a type of talk therapy for insomnia that is cheap, relatively brief and usually effective, but not currently a part of standard treatment.

The new report, from a team at Ryerson University in Toronto, found that 87 percent of patients who resolved their insomnia in four biweekly talk-therapy sessions also saw their depression symptoms dissolve after eight weeks of treatment, either with an antidepressant drug or a placebo pill -- almost twice the rate of those who could not shake their insomnia.

Those numbers are in line with a previous pilot study of insomnia treatment at Stanford.

In an interview, the report's lead author, Colleen E. Carney, said, "The way this story is unfolding, I think we need to start augmenting standard depression treatment with therapy focused on insomnia."

<snip>

Doctors have long considered poor sleep to be a symptom of depression that would clear up with treatments, said Rachel Manber, a professor in the department of psychiatry and behavioral sciences at Stanford, whose 2008 pilot trial of insomnia therapy provided the rationale for larger studies.

"But we now know that's not the case," she said. "The relationship is bidirectional -- that insomnia can precede the depression."

<snip>

The therapy that Dr. Manber, Dr. Carney and the other researchers are using is called cognitive behavior therapy for insomnia, or CBT-I for short.

The therapist teaches people to establish a regular wake-up time and stick to it; get out of bed during waking periods; avoid eating, reading, watching TV or other activities in bed; and eliminate daytime napping.

The aim is to reserve time in bed for only sleeping and -- at least as important -- to "curb this idea that sleeping requires effort, that it's something you have to fix," Dr. Carney said.

"That's when people get in trouble, when they begin to think they have to do something to get to sleep."

This kind of therapy is distinct from what is commonly known as sleep
hygiene: exercising regularly, but not too close to bedtime, and avoiding coffee and too much alcohol in the evening.

These healthful habits do not amount to an effective treatment for insomnia.

In her 2008 pilot study testing CBT-I in people with depression, Dr. Manber of Stanford used sleep hygiene as part of her control treatment.

She found that 60 percent of patients who received seven sessions of the talk therapy and an antidepressant fully recovered from their depression, compared with 33 percent who got the same drug and the sleep-hygiene therapy.

<snip>

In interviews, several researchers noted that the National Institute of Mental Health had sharply curtailed funding for work in sleep treatment.

Aleksandra Vicentic, the acting chief of the agency's behavioral and integrative neuroscience research branch, said that in 2009 the funding strategy changed for sleep projects.

In an effort to illuminate the biology of sleep's impact on behavior, the agency is now focusing on how sleep affects the functioning of neural circuits.

But Dr. Vicentic added that the agency continued to fund clinical work like the depression trials.

Dr. Andrew Krystal, who is running the CBT-I study at Duke, called sleep "this huge, still unexplored frontier of psychiatry."

"The body has complex circadian cycles, and mostly in psychiatry we've ignored them," he said.

"Our treatments are driven by convenience. We treat during the day and make little effort to find out what's happening at night."

[end excerpts]

Reposted by:
Charles R. Davenport, Psy.D.
Licensed Psychologist
Charles R. Davenport, Psy.D., LLC.
Offices: Sarasota, FL and Venice, FL


*JAMA*: Steep Increase in ADHD Diagnoses

In the Feb 12, 2014, Vol 311, No. 6 edition of *Journal of the American Medical Association* there is an article: "Steep Increase in ADHD Diagnoses."

Here are some excerpts:

[begin excerpts]

A recent analysis indicates that the proportion of children having a history of attention-deficit/hyperactivity disorder (ADHD) increased by 42% in less than a decade.

Investigators used data from the National Survey of Children's Health, a random-digit-dialed telephone survey, to compare the differences between 2003 and 2011 in how many parents say a health professional had ever diagnosed their child with ADHD.

Interesting snips below from the JAMA suggesting a steep increase in ADHD diagnoses.
<snip>

The 2011 prevalence rate represented more than 6.4 million children and teens nationally.

Among children and teens who ever had been diagnosed with ADHD, 82.3% had a current diagnosis, for a national 2011 prevalence of 8.8%, representing 5.1 million individuals.

Of those with a current diagnosis, 69% were taking ADHD medication.

The prevalence of current medication use from 2007 to 2011 increased most among girls aged 4 to 10 years , whites, children in households with income above the federal poverty level, and children in the Midwest.

According to the data, 6.4% of high school students were taking ADHD
medication, a figure that could warrant attention given the increasing concerns about medication abuse, misuse, and diversion.

The investigators, from the Centers for Disease Control and Prevention and the Health Resources and Services Administration, noted that the data might indicate actual increases in ADHD prevalence, but firm conclusions weren't possible.

The increases could be related to clinicians' growing confidence in treating ADHD as well as to increased awareness, educational policies, and changes in public perception....

[end excerpts]
Reposted by:
Charles R. Davenport, Psy.D.
Licensed Psychologist
Charles R. Davenport, Psy.D., LLC.
Offices: Sarasota, FL and Venice, FL



DSM5, Pharma Influences, & "Undesirable Form of Exceptionalism" in U.S.; Stats, Trends, Consequences

The new issue of the *Brown Political Review* includes an article: "A Tale of Two Codices: the DSM, ICD and Definition of Mental Illness in America."

Athena Bryan is the author.

Here are some excerpts:

[begin excerpts]

Ever since the Health Insurance Portability and Accountability Act (HIPAA) of 1996, billing an insurance company for treatment of a given health condition requires that the condition be identified to the insurance company by a code.

Although the DSM provides codes for each mental disorder, the HIPAA actually requires ICD codes - the International Classification of Diseases designations produced by the World Health Organization - for billing.

<snip>

The APA's website notes that the World Health Organization's "primary focus for the mental and behavioral disorder classification is to help countries to reduce the disease burden of mental disorders".

Thus, they imply that the intention behind the DSM can be defined in opposition to the ICD's conservative mission.

They also state that the ICD is distributed "as broadly as possible at a very low cost" while tellingly noting that the DSM "generates a very substantial portion of the American Psychiatric Association's revenue".

Further, the DSM revision task-force has been shown to have extensive financial connections to pharmaceutical companies: in 2009, three researchers reported to the New England Journal of Medicine that 68 percent of the DSM-V task force reported personal ties to the pharmaceutical industry.

The APA attempted to address this by requiring that the panel members have no more than $10,000 annual income from pharmaceutical sources at their time of appointment, but this did not guarantee that the income did not increase over time and additionally overlooked other economic incentives - such as grants to university labs with which panelists are associated- that could go undeclared.

When the DSM-V rolled out last spring, vocal critic Dr. Allen Frances, who chaired the revision task-force of the DSM's fourth edition, claimed it would turn "diagnostic inflation into hyperinflation and exacerbate the excessive use of medication".

<snip>

While ICD codes are ultimately used for billing insurance agencies, the DSM provides conversions to ICD codes.

Thus a medical professional can diagnose, prescribe a drug, and bill an insurer all without even being aware that the ICD is the official code system.

This is not a matter of interchangeable semantics, though, as the two systems have far from a one-to-one correspondence between disorders.

The APA points out that "it is occasionally necessary to use the same [ICD] code for more than one disorder", meaning that several DSM disorders are compiled under a single ICD code. This causes the definitions of mental illnesses to be distorted or inflated between the two systems.

In addition to increasing the number of DSM disorders encapsulated by one ICD disorder, another method of increasing pathologization becomes evident in an FAQ to help doctors to translate their DSM diagnoses to ICD billing codes.

While the DSM generates specific disorders, such as "social (pragmatic) communication disorder", "disruptive mood dysregulation disorder" and "binge eating disorder", their corresponding ICD codes are for disorders whose ICD labels are "other developmental disorders of speech and language", "other persistent mood disorders", and "other eating disorder".

Because of this, the DSM is able to circumvent the more conservative ICD criteria by overloading each ICD definition or elaborating on the "other"
category of each disorder.

Although it may seem harmless for the APA to supplement the diagnoses of the ICD, it becomes more problematic when one of the core missions of the World Health Organization - "setting norms and standards" in diagnoses and healthcare - is taken into account.

The ICD's function as a global standard is not empty rhetoric from its producers; it is overwhelmingly more popular worldwide than the DSM.

According to a study conducted by the World Health Organization across 44 countries, more than 70 percent of the responding psychiatrists use the ICD rather than the DSM.

In creating a set of standards that progressively pathologizes more of the population, the United States is pulling away from the worldwide standards in an entirely undesirable form of exceptionalism.

Motivations for this push can be ascribed to pharmaceutical companies who have been known to invest huge amounts of money to make sure their product is widely distributed.

Beyond simply looking at the Big Pharma money in the pockets of the DSM-V task-force, pharmaceutical manipulation of the DSM can be demonstrated in case studies, like the one highlighted in Academe magazine.

Author Lisa Cosgrove, a research fellow at the Edmond J. Safra Center for Ethics at Harvard, describes how the pharmaceutical company Eli Lilly argued for the use of their overwhelmingly popular antidepressant, Prozac, to treat premenstrual dysphoric disorder (PMDD).

Proving a new use for the medication allowed them to extend their about-to-expire patent, thus maintaining sole rights for its manufacture and sale.

The FDA approved this new use for Prozac, and Cosgrove argues that their approval hinged on the DSM's "subtle but key" implicit legitimization of a "check-list" approach to creating new diagnoses.

Cosgrove's 2010 article did not foresee that by 2013, PMDD would be a new addition to the DSM-V.

Today, a disorder whose diagnosis is based purely on a check-list of symptoms without consideration for the nuanced nature of mental illness has been cemented by the DSM.

<snip>

This wide-ranging influence begs the larger question as to how the United States became attached to a diagnostic manual so vulnerable to moneyed interests.

Neuroscientist and neuropsychiatrist, Nancy Andreasen, who has received the National Medal of Science, provides a potential answer in her article, "DSM and the Death of Phenomenology in America".

She argues that the United States' early, over-eager embrace of Freudian psychoanalysis, which eschews diagnosis and classification and mostly discounts patients' self-reported symptoms, prompted dissidents to provide a more clear-cut, standard set of symptom-based criteria.

In 1980, their revision of the 38-page DSM-II turned the DSM-III into a 295-page tome.

The creators of the DSM-III emphatically warned that the manual was not entirely backed up by empirical data and underlined the "importance of going beyond DSM criteria" in constructing diagnoses.

However, it became an enormously popular commodity for "anyone with any connection to psychiatry".

Both it and its successors have been "universally and uncritically accepted as the ultimate authority on psychopathology and diagnosis".

Viewed in the context of a larger reaction to the indefinite science of psychoanalysis, the impulse towards a strict, simple set of symptoms that determine diagnoses has an evident appeal.

However, its reliance on a set of criteria with a lack of data or empirical evidence would never be regarded as scientific or authoritative in any other field.

Even though the DSM has no legal foundation in the United States, increased pathologization is a conspicuous national phenomenon.

Mental illness disability rates doubled between 1987 and 2007, rates of ADHD diagnoses went from less than 5 percent in the early 1990s to 11 percent in 2013, and children being treated for bipolar disorder increased forty-fold between 1994 and 2003.

In a worldwide survey, the average mental illness rate was around ten percent while the rate in the Unites States was 26.4 percent.

[end excerpts]

Reposted by:
Charles R. Davenport, Psy.D.
Licensed Psychologist
Charles R. Davenport, Psy.D., LLC.
Offices: Sarasota, FL and Venice, FL


Do Brain Workouts Work? Science Isn't Sure

Page D-6 of the 03-14-2014 *New York Times* includes an article: "Do Brain Workouts Work?  Science Isn't Sure" by Tara Parker-Pope.

Here are some excerpts:

[begin excerpts]

For a $14.95 monthly membership, the website Lumosity promises to "train"
your brain with games designed to stave off mental decline.

<snip>

While Lumosity is perhaps the best known of the brain-game websites, with 50 million subscribers in 180 countries, the cognitive training business is booming.

Happy Neuron of Mountain View, Calif., promises "brain fitness for life."

Cogmed, owned by the British education company Pearson, says its training program will give students "improved attention and capacity for learning."

The Israeli firm Neuronix is developing a brain stimulation and cognitive training program that the company calls a "new hope for Alzheimer's disease."

And last month, in a move that could significantly improve the financial prospects for brain-game developers, the Centers for Medicare and Medicaid Services began seeking comments on a proposal that would, in some cases, reimburse the cost of "memory fitness activities."

<snip>

An effective way to stave off memory loss or prevent Alzheimer's -- particularly if it were a simple website or video game -- is the "holy grail" of neuroscience, said Dr. Murali Doraiswamy, director of the neurocognitive disorders program at Duke Institute for Brain Sciences.

The problem, Dr. Doraiswamy added, is that the science of cognitive training has not kept up with the hype.

"Almost all the marketing claims made by all the companies go beyond the data," he said.

<snip>

But questions remain whether an intervention that challenges the brain -- a puzzle, studying a new language or improving skill on a video game -- can really raise intelligence or stave off normal memory loss.

<snip>

In February 2013, however, an analysis of 23 of the best studies on brain training, led by the University of Oslo researcher Monica Melby-Lervag, concluded that while players do get better, the increase in skill hasn't been shown to transfer to other tasks.

In other words, playing Sudoku or an online matching game makes you better at the game, but it doesn't make you better at math or help you remember names or where you left your car keys.

But other studies have been more encouraging.

Last September, the journal Nature published a study by researchers at the University of California, San Francisco, that showed a driving game did improve short-term memory and long-term focus in older adults.

The findings are significant because the research found that improvements in performance weren't limited to the game, but also appeared to be linked to a strengthening of older brains over all, helping them to perform better at other memory and attention tasks.

In addition, brain monitoring during the study showed that in older participants, game training led to bursts in brain waves associated with attention; the patterns were similar to those seen in much younger brains.

In January, the largest randomized controlled trial of cognitive training in healthy older adults found that gains in reasoning and speed through brain training lasted as long as 10 years.

Financed by the National Institutes of Health, the Active study (Advanced Cognitive Training for Independent and Vital Elderly) recruited 2,832 volunteers with an average age of 74.

The participants were divided into three training groups for memory, reasoning and speed of processing, as well as one control group.

<snip>

Five years after training, all three groups still demonstrated improvements in the skills in which they had trained.

Notably, the gains did not carry over into other areas.

After 10 years, only the reasoning and speed-of-processing groups continued to show improvement.

The researchers also found that people in the reasoning and speed-of-mental-processing groups had 50 percent fewer car accidents than those in the control group.

The claims about commercial brain games are "a mixed bag," said Sherry L.
Willis, a University of Washington research professor involved in the Active study.

"There is a tendency for companies to say a certain measure represents X ability, but there may be insufficient, if any, research to support the asssertion," added Dr. Willis, who said a version of the training used in the Active study was available through Posit Science and AARP Brain Fitness.

<snip>

But while the science remains unclear, entrepreneurs have seized on what is likely to be a sizable marketing opportunity.

<snip>

While there is no real risk to participating in the many unproven brain-training games available online and through smartphones, experts say, consumers should know that the scientific jury is still out on whether they are really boosting brain health or just paying hundreds of dollars to get better at a game.

"I'm not convinced there is a huge difference between buying a $300 subscription to a gaming company versus you yourself doing challenging things on your own, like attending a lecture or learning an instrument," Dr.
Doraiswamy said.

"Each person has to personalize for themselves what they find fun and challenging and what they can stick with."

[end excerpts]

Reposted by:
Charles R. Davenport, Psy.D.
Licensed Psychologist
Charles R. Davenport, Psy.D., LLC.
Offices: Sarasota, FL and Venice, FL

Are Gifted Children Getting Lost in the Shuffle?

Are Gifted Children Getting Lost in the Shuffle?
New 30-year study of the exceptionally smart sheds light on ‘Who Rises to the Top?'

Snip: Newswise — Gifted children are likely to be the next generation's innovators and leaders—and yet, the exceptionally smart are often invisible in the classroom, lacking the curricula, teacher input and external motivation to reach full potential.

This conclusion comes as the result of the largest scientific study of the profoundly gifted to date, a 30-year study conducted by researchers at Vanderbilt University’s Peabody College of education and human development. Unsnip

Snip: Despite their remarkable success, researchers concluded that the profoundly gifted students had experienced roadblocks along the way that at times prevented them from achieving their full potential. Typical school settings were often unable to accommodate the rapid rate at which they learned and digested complex material. When students entered elementary and high school classrooms on day one having already mastered the course material, teachers often shifted focus away from them to those struggling with the coursework. This resulted in missed learning opportunities, frustration and underachievement, particularly for the exceptionally talented, the researchers suggest.
Unsnip

Released: 1/6/2014 1:00 PM EST
Source Newsroom: Vanderbilt University
Citations: Psychological Science

Reposted by:
Charles R. Davenport, Psy.D.
Licensed Psychologist
Charles R. Davenport, Psy.D., LLC.
Sarasota, FL and Venice, FL Offices